| 释义 |
quinacrine Pharm.|ˈkwɪnəkriːn|
[f. quinine + acridine.]
A name for mepacrine (hydrochloride). Also attrib. and in Comb., esp. with reference to the use of quinacrine or quinacrine mustard to stain chromosomes.
Formerly a proprietary term in the U.S.
1934Official Gaz. (U.S. Patent Office) 23 Oct. 771/1 Société des Usines Chimiques Rhone-Poulenc, Paris... Quinacrine... Pharmaceutical product to be used in the treatment of malaria. Claims use since Feb. 20, 1933. 1934Chem. Abstr. XXVIII. 3792 Quinacrine is chloro-2-diethylaminopentylamino-5-methoxy-7-acridine dihydrochloride. 1936Trade Marks Jrnl. 4 Mar. 267/1 Quinacrine... Chemical substances used in medicine and pharmacy. Société des Usines Chimiques Rhone-Poulenc,..Paris..; manufacturers. 1960C. Achebe No Longer at Ease xi. 105 He said the poor man must be suffering from malaria, and the next day he bought him a tube of quinacrine. 1970Nature 6 June 897/1 The quinacrine staining test shows up the number of Y chromosomes in a human interphase (non-dividing) cell. Ibid. 961/2 (caption) A group of quinacrine-stained spermatozoa showing fluorescence. 1971Oxford Times 26 Mar. 2/5 Samples of fluid surrounding the foetus were treated with quinacrine dihydrochloride, an anti-malaria drug. The effect was to make the ‘Y’ chromosomes..take on a fluorescent glow when viewed through an ultra-violet microscope. 1975Fraser & Nora Genetics of Man ii. 10/1 Quinacrine binds preferentially to certain regions of metaphase chromosomes to produce characteristic banding patterns (‘Q-bands’).
2. Special Comb.: quinacrine mustard, a nitrogen mustard derived from quinacrine and used as a fluorescent stain for chromosomes.
1957R. Jones et al. in Jrnl. Org. Chem. XXII. 783/2 We here wish to report on the conversion..of 2-methoxy-6,9-dichloroacridine to 2-methoxy-6-chloro-9-[4-bis(β-chloroethyl)-amino-1-methylbutylamino]acridine (quinacrine mustard). 1970[see mustard n. 3 b]. 1970Nature 4 July 101/1 The trivial name ‘quinacrine mustard’ has been used..to describe at least two chemical species. Ibid. 101/2 May I..suggest that if authors wish to continue to use the expression ‘quinacrine mustard’ this be restricted to the true quinacrine derivative [sc. 2-methoxy - 6 - chloro - 9 - [4 - bis(2 - chloroethyl)amino - 1 - methyl-butylamino] acridine]. 1971New Scientist 18 Mar. 606/1 When hamster and bean chromosomes were stained with..quinacrine mustard, and viewed with long wave-length ultraviolet light, the chromosomes fluoresced differently along their length. |