| 释义 |
pyridoxine Biochem.|pɪrɪˈdɒksiːn, -ɪn|
Also -in.
[f. pyridine with inserted ox- 1.]
One of the three common forms of vitamin B6, a colourless, weakly basic, crystalline solid which occurs esp. in cereals, liver oils, and yeast, is also manufactured commercially, and is readily interconverted inside the body to the other forms of the vitamin, pyridoxal and pyridoxamine, with which it usu. occurs; 3-hydroxy-4,5-di(hydroxymethyl)-2-methylpyridine, C8H11NO3; = adermin.
1939[see adermin]. 1941Science 5 Dec. 545/2 In vitro experiments with pyridoxine..failed to demonstrate the presence of the unknown substance. 1948New Biol. IV. 24 Roots of a hybrid [tomato] are apparently able to synthesise pyridoxine and nicotinamide better than the roots of its parents. 1961Lancet 16 Sept. 623/1 Pyridoxine deficiency induced by these drugs is an alternative mechanism invoked to explain the liver damage, and Coursin..found low levels of circulating pyridoxal and pyridoxamine in a patient showing iproniazid toxicity. 1970L. J. Harris in J. Needham Chem. of Life vi. 164 In 1934, a second component of the vitamin B2 complex, at first called vitamin B6..and now generally known as pyridoxin, was identified. 1972Materials & Technol. V. xix. 679 Pyridoxine hydrochloride is produced commercially by synthesis... It is used in multi-vitamin preparations and in larger quantities to counteract drug effects. 1974M. C. Gerald Pharmacol. x. 182 Deficiencies of pyridoxine (vitamin B6) and niacin cause convulsions in infants and pellagra, respectively.
Now also called pyriˈdoxol [-ol].
1959Recueil des Travaux Chimiques des Pays-Bas LXXVIII. 226 (heading) An improved synthesis of vitamin B6 (pyridoxol). [Note] The name pyridoxol was proposed at the 17th IUPAC congress at Stockholm in 1953. 1966Mahler & Cordes Biol. Chem. viii. 341 Numerous nutritional studies..have established that a deficiency of pyridoxol (pyridoxine)..results in many lesions in protein metabolism. 1973Zeffren & Hall Stud. Enzyme Mechanisms viii. 157 The nutritional factor vitamin B6 was known in 1934 to be involved in protein metabolism. Chemical studies showed that its structure was 3-hydroxy-4,5-di(hydroxymethyl)-2-methylpyridine.., called pyridoxol. |