| 释义 |
pyrazinamide Pharm.|paɪər-, pɪrəˈzɪnəmaɪd|
[f. pyrazine + amide.]
A white crystalline powder, pyrazine-2-carboxamide, CH:N·CH:CH·N:C·CONH2, which is used in the treatment of tuberculosis, usu. in conjunction with other drugs.
1952Amer. Rev. Tuberculosis LXV. 515 The antituberculous activity of pyrazinamide..in mice lies between that of streptomycin and that of PAS. 1961Lancet 2 Sept. 533/2 With 1 g. of streptomycin daily on six days a week..and 1–1·5 g. of pyrazinamide in a single daily dose by mouth, 32..of the 57 patients..attained bacteriological quiescence by the end of the year. 1974R. M. Kirk et al. Surgery ii. 29/2 Ethionamide, pyrazinamide, viomyocin and capreomycin may be used in the treatment of tuberculosis when it proves resistant to the usual combination of streptomycin, INAH, and PAS. |