| 释义 |
psoralen Chem. and Pharm.|ˈsɔərəlɛn|
Also -ene |-iːn|.
[f. mod.L. Psoral-ea (f. Gr. ψωραλέος itchy, mangy), generic name of an Indian leguminous herb, P. corylifolia, from seeds of which it was first isolated + -en (cf. -ene).]
A crystalline tricyclic lactone, C11H6O3, containing fused coumarin and furan ring systems, which occurs in certain plants and is taken orally or applied in ointments to treat certain skin disorders; any derivative of this compound.
1933H. S. Jois et al. in Jrnl. Indian Chem. Soc. X. 46 A petroleum ether extract of the seeds of Psoralea corylifolia gave a dark reddish-brown oil and a crystalline solid C11H6O3 now named Psoralen, melting at 162°. 1959N. Campbell in E. H. Rodd Chem. Carbon Compounds IVb. viii. 883 Examples of the furocoumarins are found in psoralene and angelicin, which differ from each other in the points of attachment of the furan ring to the aromatic nucleus of coumarin. 1969Observer 26 Jan. 5/5 Patients who are prescribed psoralens—drugs sensitive to ultra-violet light and taken to bring a healthy glow back to unnaturally white patches of skin—should resist the temptation to use them as ‘suntan pills’. 1978Lancet 11 Mar. 538/1 Psoralens form photoadducts and interstrand cross-links with d.n.a. in the presence of u.v.-A. and mounting evidence indicates that these events are mutagenic. |