| 释义 |
base pair, n. Biochem.|beɪsˈpɛə(r)|
[f. base n.1 + pair n.1]
A pair of complementary bases held together by hydrogen bonding and occurring in sequences in the strands of DNA and RNA molecules; such a pair as a unit in which to express the size of a nucleic acid molecule.
1956Proc. Nat. Acad. Sci. XLII. 61 The base pairs resulting from the above considerations are listed. 1957Cold Spring Harbor Symp. Quant. Biol. XXI. 89/2 We know that the hydrogen bonds in DNA can be readily broken by heating, but the value of the activation energy of this process indicates that the bonds reform unless they are broken in about 15 consecutive base-pairs. 1975Nature 12 June 530/1 More recent work using nucleases has shown that the DNA in chromatin exists in some regular fold which repeats every 200 base pairs, the best value currently being 205{pm}15 base pairs. 1988Economist 20 Feb. 83/1 ‘What is man, that thou art mindful of him?’ asked the psalmist. To some molecular biologists,..the answer is a list of 3 billion ‘base pairs’ of deoxyribonucleic acid. 1993N.Y. Rev. Bks 12 Aug. 52/1 A group of my colleagues managed to recover nearly the entire sequence—1320 of 1431 base pairs—of a chloroplast gene prominently involved in photosynthesis.
So ˈbase pairing vbl. n., the combining of two bases to form a base pair; an instance of this; hence (as a back-formation) ˈbase-pair v. intr., to pair in this way; also, ˈbase-paired ppl. a.
1956Proc. Nat. Acad. Sci. XLII. 62 This base-pairing scheme is shown in Figure 2, where it is seen that Nbase—Csugar bonds are related by a twofold axis parallel to the helical axis. 1959Brookhaven Symp. Biol. XII. 39 There is a second class of base, which won't base pair, but these are not found in the RNA of tobacco mosaic virus or in DNA. 1960V. R. Potter Nucleic Acid Outl. I. iii. 83 These figures describe the spatial relationships for the four possible base pairings found in the double helix. 1970Proc. Nat. Acad. Sci. LXVII. 1473 Two shorter duplexes, each containing one base-paired end and one protruding single-stranded end were also studied. 1988P. W. Kuchel et al. Schaum's Outl. Theory & Probl. Biochem. vii. 183 DNA is a duplex molecule in which two polynucleotide chains (or strands) are linked to one another through specific base pairing. 1988Nature 24 Nov. 399/1 The frequency of mismatches within the basepaired region..will..influence..the effective life of the mRNA. 1989B. Alberts et al. Molecular Biol. Cell (ed. 2) i. 7 (caption) By base-pairing to a coding RNA molecule, these RNA molecules allow an RNA sequence to act as a template for the synthesis of amino acid polymers. |