| 释义 |
ristocetin Pharm.|rɪstəʊˈsiːtɪn|
[Arbitrarily formed; -cetin f. actinomycetes + -in1.]
An antibiotic substance (now known to be a mixture) obtained from the actinomycete Nocardia lurida and formerly used to treat staphylococcal infections.
1957W. E. Grundy et al. in Antibiotics Ann. 1956–7 687 A new antibiotic that has been given the generic name ristocetin was isolated from the fermentation beer of an actinomycete. 1960M. E. Florey Clin. Appl. Antibiotics IV. iii. 77 Isolated from the fermentation liquor of an unidentified actinomycete called by the authors Nocardia lurida and obtained from soil at Colorado Springs, ristocetin gives promise of being of value in the treatment of staphylococcal and other infections. 1968J. H. Burn Lect. Notes Pharmacol. (ed. 9) 111 Vancomycin and ristocetin do not appear to induce the emergence of resistant staphylococci. 1980Brit. Med. Jrnl. 18 Oct. 1039/1 The coagulation studies were diagnostic of Glanzmann's thrombasthenia with diminished platelet aggregation in response to ristocetin. |