| 释义 |
prostaglandin Biochem.|prɒstəˈglændɪn|
[a. G. prostaglandin (U. S. von Euler 1935, in Klin. Wochenschr. 17 Aug. 1183/1), f. G. prosta(ta or Eng. prostate n. (a.) + gland2 + -in1.]
Any of a group of closely related unsaturated, oxygenated, cyclic fatty acids which occur in seminal fluid and many tissues in male and female mammals and have numerous marked physiological effects (notably the contraction of smooth muscle, esp. that of the uterus). Cf. next.
1936U. S. von Euler in Jrnl. Physiol. LXXXVIII. 233 In secretion and extracts from the prostate and seminal vesicles of man and the vesicular gland of the sheep a pharmacodynamically highly active substance, prostaglandin, has been demonstrated. 1957Acta Chem. Scand. XI. 1086/1 We have succeeded in obtaining one ‘prostaglandin’ factor (PGF) in crystalline form. 1960Ibid. XIV. 1693 (heading) The isolation of prostaglandin F from sheep prostate glands. 1965Sun 2 Nov. 11/1 It is thought that prostaglandins may work by acting on the woman's reproductive muscles, so helping the process of conception. 1970New Scientist 3 Sept. 468/1 All 14 of the closely related prostaglandins discovered so far occur naturally in minute amounts in the human body. 1971Daily Tel. 15 Oct. 2/2 An extra dose of prostaglandins is being tried as a ‘once-a-month’ pill for women, but a deficiency of prostaglandins in semen has been associated with infertility. 1973J. R. Weeks in Kahn & Lands Prostaglandins & Cyclic AMP 2 The prostaglandins are among the most potent substances known, acting in some systems at concentrations of 0·01 ng/ml in vitro. 1977Martindale's Extra Pharmacopoeia (ed. 27) 1328/2 An important source of prostaglandins is the cortex of a Gorgonia coral, Plexaura homomalla or sea whip, from the Caribbean. 1979F. H. Stewart et al. My Body, my Health i. 17 Researchers suspect that prostaglandin released by the uterus may play a role in menstrual cramps. |