| 释义 |
Premarin Pharm.|prɪˈmɛərɪn|
Also premarin.
[f. pregnant a.2 + mare1 + -in1.]
A proprietary name for a mixture of œstrogenic compounds obtained from the urine of pregnant mares and used in the treatment of various conditions, esp. those caused by or involving œstrogen deficiency.
1942Official Gaz. (U.S. Patent Office) 21 July 498/1 Ayerst, McKenna & Harrison (United States) Limited, Rouses Point, N.Y... Premarin. For pharmaceutical preparations for the treatment of ovarian deficiencies. Claims use since Feb. 24, 1942. 1944Jrnl. Amer. Med. Assoc. 19 Aug. 1098/2 Premarin.—An amorphous preparation containing the naturally occurring, water soluble, conjugated forms of the mixed estrogens obtained from the urine of pregnant mares. Ibid., Premarin Tablets. 1956Trade Marks Jrnl. 2 May 312/1 Premarin... Estrogenic preparations. Ayerst, McKenna & Harrison, Limited.., St. Laurent, Quebec, Canada; manufacturers and merchants. 1961Lancet 2 Sept. 504/2 In these patients continued administration of premarin resulted in a suggestive, though inconclusive, improvement in mortality as compared with a comparable control group. 1977Ibid. 19 Nov. 1063/1 A two to three fold increase in the incidence of ovarian cancer was recorded in women treated for menopausal symptoms with ‘Premarin’ (conjugated equine œstrogens) usually combined with stilbœstrol. |