| 释义 |
pregnenolone Biochem. and Med.|prɛgˈniːnələʊn|
[ad. G. pregnenolon (Butenandt & Westphal 1934, in Ber. d. Deut. Chem. Ges. LXVII. 2085), f. pregn-an pregnane + -en -ene + -ol -ol + -on -one.]
A synthetic steroid, C21H32O2, which is a reduced derivative of progesterone and was formerly used in the treatment of rheumatoid arthritis.
1936Chem. Abstr. XXX. 3036 Similar mixts. of III and I or III and pregnenolone (IV) met with in the prepn. of the hormone from stigmasterol can be sepd. in the same manner. 1955Jrnl. Amer. Med. Assoc. 21 May 166/1 All the patients had received, at one time or another, gold salts, pregnenolone, antibiotics, [etc.]..that produced, at the most, only palliative relief. 1964E. J. W. Barrington Hormones & Evolution ii. 54 In this way cholesterol is thought to be transformed into progesterone, through the intermediary pregnenolone, by partial degradation of its side chain. 1967Martindale's Extra Pharmacopoeia (ed. 25) 1543/2 Pregnenolone and pregnenolone acetate have been used in the treatment of rheumatoid arthritis..but their value has not been substantiated. |