| 释义 |
pregnanediol Biochem. and Med.|ˌprɛgneɪn-, ˌprɛgnənˈdaɪɒl|
Also pregnandiol.
[ad. G. pregnandiol (A. Butenandt 1930, in Ber. d. Deut. Chem. Ges. LXIII. 660), f. L. prægnan-s pregnant + G. di- di-2 + -ol -ol; cf. pregnane.]
A crystalline steroid containing two hydroxyl groups, C21H36O2, which is a product of the metabolism of progesterone and occurs in the urine during pregnancy.
1930Chem. Abstr. XXIV. 2785 Pregnandiol is related to the sterols and gallic acid. 1934Jrnl. Biol. Chem. CVII. 324 It also seems possible that our compounds may be related to pregnandiol. 1934Ann. Rep. Progr. Chem. XXX. 216 Pregnanediol..is a physiologically inactive compound found in the urine during pregnancy. 1955Sci. Amer. Jan. 55/3 In pregnancy urine there was found an inactive companion of estrone, called pregnanediol. Butenandt proved that pregnanediol was related to cholic acid, a component of bile, by breaking both down to a common product. 1961Lancet 5 Aug. 277/2 The relationship between myometrial progesterone and pregnanediol in the urine is even less clearly defined. 1968Passmore & Robson Compan. Med. Stud. I. xxxi. 13/1 Progesterone is reduced to pregnanediol, which is excreted as sulphate or glucuronide conjugates. 1976Path. Ann. XI. 240 In 1946 Smith, Smith, and Hurwitz reported that stilbestrol administered to pregnant women increased urinary pregnanediol levels. |