| 释义 |
plasmin Chem.|ˈplæzmɪn|
[ad. F. plasmine, f. plasm-a + -ine, -in1.]
†1. A proteid substance obtained from the plasma of the blood, soluble in water, the solution coagulating into fibrin. Obs.
1866Watts Dict. Chem. IV. 662 Plasmin,..applied by Denis (Compt. rend. lii. 1239; Jahresb. 1861, p. 725) to a constituent of the blood to which he supposes the property of spontaneous coagulation to be due... It is soluble in water... The solution..solidifies after a few minutes to a colourless transparent jelly, which by pressure between paper is converted into fibres of fibrin. 1876Foster Phys. i. i. (1879) 15 The coagulation of blood is the result of the conversion of plasmine into fibrin. 1895Syd. Soc. Lex., Plasmine..is a mixture of at least two bodies, paraglobulin and fibrinogen.
2. Physiol. A proteolytic enzyme which destroys blood clots by attacking fibrin.
1945Christensen & Macleod in Jrnl. Gen. Physiol. XXVIII. 581 Under this scheme the activated enzyme may be termed ‘plasmin’ in comformity [sic] with common usage for proteases, where the prefix indicates the source of the enzyme, followed by -in... The inactive enzyme as it occurs in serum and plasma may be designated as ‘plasminogen’ to indicate its source, the plasma, and also to indicate that it is in an inactive, precursor state... The term ‘plasmin’ has been used in the past to designate a fraction of blood obtained by a special salting-out procedure. This usage, however, has become obsolete and the possibility of confusion with the proteolytic enzyme system is remote. 1962[see fibrinolysin s.v. fibrino-]. 1968Passmore & Robson Compan. Med. Stud. I. xxvi. 16/1 The active enzyme in this system, plasmin, is proteolytic but possesses a preference for fibrin as substrate. It is formed from an inactive soluble blood protein precursor, plasminogen, by the action of plasminogen activator. 1976Nature 22 Jan. 235/2 Plasminogen is the plasma proenzyme which, on conversion to its active form, plasmin, is considered responsible for lysis of fibrin deposits resulting from physiological or pathological activation of the coagulation cascade. |