| 释义 |
pizotifen, n. Pharm.|pɪˈzəʊtɪfɛn|
[f. piperidine n. + benzo- + -tifen altered f. thiophene n., after tamoxifen n., etc.]
A tricyclic drug, C19H21NS , with blocking properties at histamine and serotonin receptors, given orally in tablet form as a prophylactic in some cases of migraine.
1969WHO Chron. XXIII. 439 Pizotifen. 1971N.Z. Med. Jrnl. LXXIII. 5 (heading) The treatment of migraine with BC 105 (pizotifen): a double blind trial. 1977Lancet 11 June 1259/2 We have done a small pilot trial of pizotifen combined with maprotiline (‘Ludiomil’) in patients with depression. 1985Brit. Med. Jrnl. 9 Nov. 1337/1 Appetite may be increased by..pizotifen. 1988Pharmacology XXXVII. 252/1 In our studies, the 5-HT antagonists cyproheptadine and pizotifen..inhibited the pressor effect of 5-HT and DHE in a noncompetitive manner. |