| 释义 |
phentolamine Pharm.|fɛnˈtɒləmiːn|
[f. phen-, pheno- + tolyl + amine.]
A white or cream-coloured heterocyclic solid, C17H19N3O, which is used (in the form of its salt) as a vasodilator, esp. in the treatment of hypertension caused by phæochromocytoma.
1953Jrnl. Amer. Med. Assoc. 15 Aug. 1533/2 Phentolamine hydrochloride, a salt of phentolamine base, is suitable for oral administration and acts as a potent adrenergic blocking agent, producing adrenolytic and sympatholytic effects. 1961L. Martin Clin. Endocrinol. (ed. 3) vi. 182 Phentolamine is the most reliable of the adrenolytic substances both for diagnosis of phæochromocytoma and for use during its removal. 1968J. H. Burn Lect. Notes Pharmacol. (ed. 9) 8 Patients with a high blood pressure may suffer from an adrenal medullary tumour which secretes noradrenaline and adrenaline into the blood. This can be diagnosed by injecting phentolamine intravenously. 1972Materials & Technol. V. xxi. 810 Alpha receptor blockers such as tolazoline may be used in the treatment of peripheral blood vessel spasm, while phentolamine is used to treat hypertensive (high blood pressure) crises. |