| 释义 |
perforin, n. Biochem.|ˈpɜːfərɪn|
[f. perforate v. + -in1.]
A protein, released by killer cells of the immune system, which destroys targeted cells by creating pore-like lesions in their membranes.
1983Dennert & Podack in Federation Proc. XLII. 561/1 Analysis of membrane fragments by negative staining revealed the formation of two types of membrane lesions (poly perforins). 1983― in Jrnl. Exper. Med. CLVII. 1484 Based on the putative function and assembly of the tubules, we propose the following nomenclature which will be used throughout the manuscript: The monomeric precursors of T1 are designated perforin 1 (Pf 1) and their tubular polymerization product, polyperforin 1 (poly P1). 1985Jrnl. Biol. Chem. CCLX. 9072/1 Perforin assembled to polyperforin and inserted into erythrocytes in the presence of Ca2+ . 1986Jrnl. Exper. Med. CLXIV. 2077 A granule pore-forming protein (PFP, perforin or cytolysin) has been implicated in lymphocyte-mediated cell killing. 1988Sci. Amer. Jan. 31/1 If calcium ions are added to perforin before it makes contact with cells, the protein's killing activity is abolished. 1989Nature 9 Mar. 183/3 Integrating the..molecular homologies (C1q with collagen; the serine proteases; the perforins with terminal attack-proteins..) with the consequences for pathological processes. |