| 释义 |
penicillamine Chem. and Pharm.|pɛnɪˈsɪləmiːn|
[f. penicillin + amine.]
An amino-acid, (CH3)2C(SH)CH(NH2)COOH, produced by the hydrolysis of penicillins and used pharmacologically as a chelating agent; 2-amino-3-methyl-3-mercaptobutanoic acid.
1943E. P. Abraham et al. in Nature 23 Jan. 107/1 The properties of this substance, which we propose to term penicillamine, show that it represents a novel type of naturally occurring base. Ibid., Penicillamine is obtained by hydrolysing barium penicillin..at 100°C. for one hour by means of N/10 sulphuric acid. 1947Sci. News IV. 70 The synthesis of penicillin G starts with a benzyl oxazolone and with penicillamine, and attempts to recombine them. 1969[see hypogeusia s.v. hypo- II]. 1977Davidson's Princ. & Pract. Med. (ed. 12) 733 This disorder [sc. Wilson's disease]..can now be arrested by giving copper-binding drugs (chelating agents)... The most valuable of these is penicillamine. |