| 释义 |
paralogous,, a. Biol.|pəˈræləgəs|
[f. para-1 after homologous a.]
Of two or more genes, esp. in different species: descended from a single gene by gene duplication in the course of evolution. Also, characterized or produced by such genes. Cf. *orthologous a.
1970Fitch & Margoliash in Evolutionary Biol. IV. 76 Following a gene duplication, both genes may evolve different functions while descending side by side in the same phyletic lineage. Such genes may be called paralogous (para = in parallel) and an example might be human myoglobin and α hemoglobin. 1971Nature 29 Jan. 323/2 Sequences suspected to have a paralogous relationship were tested by an empirical method, partly developed by Dayhoff and Eck. 1977Ibid. 28 Apr. 804/1 He states that ‘the tRNAs are mostly paralogous’, which was news to me, because there are many examples of homologous tRNAs for the same amino acid occurring in related species of organisms. 1987Molecular Biol. & Evol. IV. 81 One may repeat the analysis using the paralogous A and E genes.
Hence paˈralogously adv.
1970[see orthologously adv. (s.v. orthologous a.)]. 1979Systematic Zool. XXVIII. 158/1 As illustrated by the case of hominoid delta chains which are found along with beta chains in adult hominoid red blood cells, there is usually compelling biological evidence to show that such chains are paralogously related to a set of orthologous ones. |