释义 |
pamaquin Pharm.|ˈpæməkwɪn| Also -ine. [f. pentyl + amino- + methoxy- + -a- + quinoline.] An orange-yellow crystalline salt, C19H29N3O.C23H16O6, which is a toxic compound formerly used in the treatment of malaria. Cf. Plasmochin, Plasmoquine.
1941Brit. Pharmacopœia 1932 Add. iv. 24 Pamaquin is the 6-methoxy-8-[ω-diethylamino-α-methylbutyl]-aminoquinoline salt of 2:2′-dihydroxy-1:1′ -dinaphthylmethane-3:3′-dicarboxylic acid. 1951A. Grollman Pharmacol. & Therapeutics xxxiii. 483 Because of its toxicity and the availability of safer and better drugs, pamaquine is no longer of therapeutic importance. 1961New Scientist 4 May 261/1 The anti-malarial drugs pamaquin and primaquine produce anaemia in certain susceptible persons. 1974B. G. Maegraith in A. W. Woodruff Med. in Tropics ii. 65/1 The 8-aminoquinoline most widely given [for vivax malaria] is primaquine; pamaquine or quinocide are alternatives. |