英语词汇“oxotremorine”的英英意思、用法、释义、翻译、读音、例句、短语、词组-英语词典

单词	oxotremorine
释义	oxotremorine Pharm.\|ɒksəʊˈtrɛməriːn\| [f. oxo- + tremorine.] A crystalline compound, 1-(2-oxopyrrolidino)-4-pyrrolidino-2-butyne, C₁₂H₁₈N₂O, a metabolite of tremorine, which is capable of inducing the symptoms of Parkinsonism and is used in research into this disease. 1961A. K. Cho et al. in Biochem. & Biophys. Res. Communications V. 276 For purposes of rough measurement, a unit was defined as the dose per Kg. which on intravenous injection in mice gave this threshold effect. It proved to be equal to approximately 15 µg. of 2-oxotremorine base.1970Passmore & Robson Compan. Med. Stud. II. v. 560/2 Another method [of inducing symptoms of Parkinsonism] involves the use of the drug tremorine..or its active metabolite oxotremorine which induce tremor, rigidity, akinesia, analgesia and signs of peripheral cholinergic stimulation in many animal species.1972Brimblecombe & Pinder Tremors iv. 96 Leslie & Maxwell (1964) first suggested that oxotremorine is a more desirable tool in screening compounds for anti-Parkinson activity than is tremorine.
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