| 释义 |
oncogene Biol.|ˈɒŋkədʒiːn|
[f. onco- + gene1.]
A gene in a virus particle held to be responsible for transforming a host cell into a tumour cell.
1969Huebner & Todaro in Proc. Nat. Acad. Sci. LXIV. 1087 It is postulated that the viral information (the virogene), including that portion responsible for transforming a normal cell into a tumor cell (the oncogene), is most commonly transmitted from animal to progeny animal and from cell to progeny cell in a covert form. 1970New Scientist 3 Sept. 465/2 Occasionally, an ‘oncogene’ of the virus becomes switched on, and the host cell is transformed into a cancer cell. 1971Nature 6 Aug. 373/2 Attempts to analyse genetically the oncogenes in adenovirus genomes, by the isolation of temperature sensitive mutants, seem most promising. 1975Ibid. 7 Aug. 498/1 The oncogene theory contends that type C viruses possess oncogenic information and that malignancy is the result of activation of this genetic information. |