| 释义 |
novobiocin Pharm.|nəʊvəʊˈbaɪəsɪn|
[prob. f. as next + bio- + -mycin.]
A weakly acidic tetracyclic phenol, C31H35N2O11, that is produced by certain actinomycetes of the genus Streptomyces and is used in treating infections with bacteria resistant to less toxic antibiotics; also, the sodium or calcium salt of this phenol, in which forms it is usually administered.
1956Antibiotics & Chemotherapy VI. 195 It has been announced that by mutual agreement of The Upjohn Co. and of Merck & Co., Inc., the generic name of novobiocin would be used for the antibiotic previously called streptonivicin and cathomycin. 1961Lancet 23 Sept. 688/2 Kanamycin..was changed to a combination of erythromycin..with novobiocin 500 mg. six-hourly. 1967Martindale's Extra Pharmacopoeia (ed. 25) 990/1 The usefulness of novobiocin is limited by the frequent occurrence of side-effects. Ibid., Novobiocin sodium is usually administered by mouth. 1972Jrnl. Pharmacy & Pharmacol. XXIV. 972 Novobiocin..is used infrequently because micro-organisms rapidly develop resistance to it. |