| 释义 |
non-steroidal, a. and n. Pharmacol.
Brit. |ˌnɒnstɛˈrɔɪdl|, |ˌnɒnstɪəˈrɔɪdl|, U.S. |ˌnɑnstɛˈrɔɪd(ə)l|, |ˌnɑnstɪˈrɔɪd(ə)l|
[‹ non- prefix + steroidal adj. at steroid n. Derivatives.]
A. adj.
1. That does not have the chemical structure of a steroid; spec. that is not an adrenal or gonadal steroid hormone.
1952Science 4 Apr. 377/2 Incubation of their blood..with nonsteroidal microcrystals (e.g. sulfonamides), had only slight effects on the level of eosinophils. 1965Acta Pharmacologica et Toxicologica 23 365 The search for new non-steroidal oestrogens has mainly been concentrated on derivatives of stilbene. 1977Ann. Internal Med. 86 222/1 The most studied nonsteroidal immunosuppressive agents have been azathioprine and cyclophosphamide. 2002Jrnl. Pharmacol. & Exper. Therapeutics 302584 Tamoxifen, a nonsteroidal antiestrogen, is used widely in the treatment of breast cancer.
2. That does not use, contain, or involve steroids (spec. corticosteroids or sex steroids); (also) that uses or involves non-steroidal anti-inflammatory drugs (see Special uses).
1963Arthritis & Rheumatism 6 36 The anti-UV-erythema efficacy is closely correlated with and highly predictive of a nonsteroidal kind of antirheumatic efficacy. 1981Brit. Jrnl. Obstetr. & Gynaecol. 88 919 Naloxone may provide the basis for a non-steroidal treatment of climacteric flushing attacks. 1987Today's Health Apr.–May 52/1 Protecting the mucosa from the irritating effects of long-term non-steroidal treatment. 1995Animals' Voice Winter 16 If nonsteroidal therapy is ineffective then corticosteroids, such as prednisone or prednisolone, are sometimes prescribed. 1999Daily Tel. 8 June 20/3 She takes..two puffs of Bricanyl, her non-steroidal inhaler, up to four times a day.
B. n. A non-steroidal anti-inflammatory drug.
1982Rheumatol. & Rehabilitation 21 187 (title) Non-steroidals ineffective in OA? 2001Oncologist 6 353 Other suggested beneficial effects of estrogen such as colon cancer prevention can be approached by the use of aspirin or the non-steroidals.
Special uses. non-steroidal anti-inflammatory agent n. = non-steroidal anti-inflammatory drug n.
1963Arthritis & Rheumatism 6 44 CI-440 would seem to be the most potent *nonsteroidal anti-inflammatory agent yet reported. 1997B. Rowlands Which? Guide Complementary Med. 109 The herbs may contain..conventional drugs (corticosteroids, paracetamol, non-steroidal anti-inflammatory agents, benzodiazepines).
non-steroidal anti-inflammatory drug n. any of a group of non-steroidal compounds having anti-inflammatory effects (chiefly inhibition of prostaglandin synthesis), used especially in the treatment of arthritis and other inflammatory musculoskeletal disorders, as analgesics for mild to moderate pain (of headache, dysmenorrhoea, etc.), and as antipyretics; abbreviated NSAID.
1966Proc. Soc. Exper. Biol. & Med. 123707 (title) Effect of *non-steroidal anti-inflammatory drugs in the Evans Blue pleural effusion. 2002Ann. Allergy, Asthma & Immunol. 88 331 Adverse reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) are very common problems. |