| 释义 |
nitrofurantoin Pharm.|ˌnaɪtrəʊfjʊəˈræntəʊɪn|
[f. nitro- + fur-furyl (f. furfur-ol + -yl) + hydantoïn in the chemical name of the compound, 1-(5-nitrofurfurylideneamino)-hydantoïn.]
A yellow crystalline bicyclic compound, C8H6N4O5, which is an antibacterial agent used in treating infections of the urinary tract.
1953Antibiotics & Chemotherapy III. 151 A new anti⁓bacterial nitrofuran, Furadantin, Eaton, brand of nitrofurantoin. 1963Amer. Rev. Respiratory Dis. LXXXVIII. 712/2 Most tubercle bacilli with increased resistance to isoniazid also manifest increased susceptibility to nitrofurantoin. 1972M. Rowland in Melmon & Morrelli Clin. Pharmacol. ii. 30/2 The most common side effect associated with nitrofurantoin is gastrointestinal irritation and occasional emesis due to a central action of the drug, probably dependent on high concentrations of nitrofurantoin in blood. |