| 释义 |
Nissl Med.|ˈnɪs(ə)l|
The name of Franz Nissl (1860–1919), German neurologist, used attrib. and in the possessive to designate esp. a methylene blue stain (Nissl('s) stain) used for the cell bodies of neurones; the application of this stain (Nissl('s) method); and hence the small cytoplasmic structures (Nissl('s) bodies, Nissl granules) revealed in the cell bodies of neurones by this method. Also Nissl degeneration, degeneration of the cell bodies of neurones, accompanied by disappearance of their Nissl bodies; Nissl('s) substance, the Nissl bodies collectively.
1898Jrnl. Mental Sci. XLIV. 730 The Nissl bodies.., which stain deeply with basic dyes. 1899Jrnl. R. Microsc. Soc. 448 (heading) New Nissl method. 1899L. F. Barker Nervous System 110 He thinks it very wrong that these should be thrown all together and designated either ‘Nissl's substance’ or ‘tigroid substance’. 1901Jrnl. Exper. Med. V. 551 The principles of Nissl's method are extremely simple. Ibid. 553 A definite reaction to the Nissl stain. Ibid. 554 He finds the Nissl granules embedded in a homogeneous coagulum-like mass. 1905Gould Dict. New Med. Terms 129/1 Staining with Nissl's stain (methylene-blue). 1911Stedman Med. Dict. 586/2 Nissl degeneration. 1933Amer. Jrnl. Anat. LIII. 153 The cells are indeed very light; the Nissl substance is scanty. 1943Strong & Elwyn Human Neuroanat. iii. 28/1 The significance of the Nissl stain..lies in the fact that..each type of nerve cell always presents the same appearance or ‘equivalent picture’ in normal conditions. 1966Wright & Symmers Systemic Path. II. xxxiv. 1147/1 In the cytoplasm of the neuron, certain polygonal, basiphile structures, known collectively as Nissl substance, are present. 1968Passmore & Robson Compan. Med. Studies I. xiv. 2/2 Nissl granules are present in the perikaryons of all neurones. 1971Sci. Amer. July 48/2 The Nissl method made it possible to outline and identify well-defined regions in the brain. 1971J. Z. Young Introd. Study Man xi. 147 Nerve cells are characterized by a large amount of ribonucleic acid in the cytoplasm—the basophilic Nissl bodies. 1974Passmore & Robson Compan. Med. Studies III. ii. xxxiv. 33/2 The parent cell bodies undergo central chromatolysis (Nissl degeneration). |