| 释义 |
neomycin Pharm.|niːəʊˈmaɪsɪn|
[f. neo- + -mycin.]
An antibiotic that is a mixture of two stereoisomers produced by a selected strain of Streptomyces fradiæ, is active against many strains of Gram-positive and Gram-negative bacteria, and is used (as the sulphate) in lotions and injections for treating a wide variety of infections and orally as an intestinal antiseptic; also, either of the two constituent isomers (neomycin B and neomycin C) or an inactive degradation product of them (neomycin A).
1949Waksman & Lechevalier in Science 25 Mar. 305/2 In search for new compounds, particular attention was paid to those that would be effective against streptomycin-resistant bacteria, notably against the streptomycin-resistant strains of M[ycobacterium] tuberculosis. The discovery of such an agent, designated as neomycin, is reported here. 1949R. L. Peck et al. in Jrnl. Amer. Chem. Soc. LXXI. 2590/2 Evidence has been obtained that the neomycin activity is due to more than one chemical entity; hence one may define it as a ‘neomycin-complex’. The substance isolated as described herein, has been designated neomycin A. 1960M. E. Florey Clinical Applications of Antibiotics iv. v. 140 Neomycin..was expected to replace streptomycin since it was much less liable to induce resistance in pathogenic organisms. 1963Lancet 19 Jan. 161/2 The infant [sc. a Salmonella heidelberg excretor] was treated with neomycin, and thereafter all specimens were negative. 1970Passmore & Robson Compan. Med. Stud. II. xx. 30/1 Neomycin and kanamycin reduce ventilation during general anaesthesia by a neuromuscular blocking action. 1974M. C. Gerald Pharmacol. iii. 45 The antibiotic neomycin is used to sterilize the gastrointestinal tract prior to abdominal surgery. |