释义 |
Myleran Pharm.|ˈmaɪləræn| A proprietary name for 1,4-di(methanesulphonyloxy)butane, C6H4O6S2, which is a cytotoxic agent with a selective action on bone marrow and is used in the treatment of myeloid leukæmia.
1952Trade Marks Jrnl. 12 Nov. 1049/1 Myleran... The Wellcome Foundation Limited, .. London, ..manufacturing chemists. 1953Lancet 31 Jan. 207/2 ‘Myleran’..showed an intense inhibitory effect on the growth of the Walker rat carcinoma 256. 1959Progr. Hematol. II. 227 With Myleran,..the margin between the therapeutic dose and the toxic dose, producing irreversible aplastic change in the bone marrow, is relatively narrow. 1968Internat. Pharmacol. Abstr. V. 1509 A 26-year-old woman had to be treated with busulphan (Myleran), 2–8 mg. daily during the first to sixth and 19–30th weeks of pregnancy because of chronic myeloid leukemia. |