| 释义 |
antisense, a. Biochem. and Genetics.|ˈæntisɛns|
[f. anti-1 + *sense n. 29 c.]
Designating or pertaining to the strand of duplex DNA that acts as a template for the synthesis of mRNA in a cell; also, designating or pertaining to RNA produced by the transcription of sense DNA, having a complementary base sequence to mRNA and able to bind with it, thereby preventing translation of the latter into protein. Also absol. as n.
For an antithetical use see note s.v. *sense n. 29 c.
1977Biochem. & Biophys. Res. Communications LXXV. 602 The synthesis of the ‘anti-sense’ strand, and its pairing with globin RNA sequences, are processes that will presumably occur in the absence of Hg-substituted precursors. 1979Jrnl. Molecular Biol. CXXXV. 729 A fraction of h22 transcripts from the oocyte must be considered as erroneous since they are derived from the antisense strand of histone DNA whereas in the sea urchin only the sense strand is transcribed. 1988Nature 30 June 801/1 Anti-sense RNA..is complementary to a given messenger RNA species, with which it pairs, forming double-stranded RNA. 1990Food FIPP Apr. 2/2 Antisense tomatoes are engineered with a gene that significantly reduces the naturally occurring enzyme polygalacturonase. 1991Daily Tel. 27 May 18/5 The scientists inserted an antisense genetic sequence into the chromosomes of fertilised mouse eggs. 1993W. Bains Biotechnol. 19 Antisense was discovered as the way that some bacteria naturally regulate the activity of some of their genes. |