| 释义 |
Michaelis–Menten, n. Biochem.|mɪˌkeɪlɪsˈmɛntən|
[f. the name of Lenor Michaelis (see *Michaelis n.) + the name of Maud Lenore Menten (1879–1960), American physician.]
Used attrib. to designate (a) a model of enzyme action which assumes the formation of an intermediate complex of enzyme and substrate; (b) a rate equation associated with this model.
1947Sumner & Somers Chem. & Methods Enzymes (ed. 2) i. 20 The Michaelis-Menten hypothesis has also been extended to include equilibria involving enzyme, coenzyme, substrate, and hydrogen ions. 1954H. B. Bull in McElroy & Glass Symp. on Mechanism of Enzyme Action ii. 141 The Michaelis-Menten rate expression is a composite equation combining zero- and first-order kinetics. 1984S. D. Shorvon Epilepsy 21/2 The best example of this is that of phenytoin, which exhibits Michaelis–Menten kinetics, often with a steeply rising curve at serum levels which are clinically important. 1990Jrnl. Exper. Bot. XLI. 930/1 The deterioration in photosynthetic performance can be predicted from simple Michaelis–Menten kinetics..for two competitive substrates. |