| 释义 |
metyrapone Pharm.|mɛˈtɪ-, mɛˈtaɪərəpəʊn|
[f. 2-methyl-1,2-di(pyrid-3-yl)propan-1-one, the chemical name (f. methyl + di-2+ pyridyl + propane + -one), with insertion of a.]
A whitish crystalline compound, C5H4N·CO·C(CH3)2·C5H4N, which inhibits the synthesis of cortisone and hydrocortisone and is used for testing the function of the anterior pituitary.
1962Lancet 8 Dec. 1199/1 This paper reports the prevention of massive adrenal necrosis due to d.m.b.a. by the concurrent administration of metyrapone. 1970Passmore & Robson Compan. Med. Stud. II. vi. 14/2 The metyrapone test depends upon the fact that the feedback control mechanism between the adrenal cortex and the hypothalamo–pituitary axis is mediated by the circulating concentration of unbound cortisol. 1973Clin. Pharmacol. & Therapeutics XIV. 455 After 1 year of treatment urinary steroids and their responses to oral metyrapone were unchanged. |