| 释义 |
methadone Pharm. orig. U.S.|ˈmɛθədəʊn|
Also -on |-ɒn|.
[f. methyl + amino- + di-2 + -one in 6-dimethylamino-4, 4-diphenyl-3-heptanone, the systematic chemical name.]
A powerful synthetic analgesic, (CH3)2N·CH(CH3)·CH2·C(C6H5)2·CO·CH2·CH3, which is similar to morphine in its effects but less sedative and is used (usu. as the hydrochloride) as a substitute drug in the treatment of addiction to morphine or heroin.
1947Jrnl. Amer. Med. Assoc. 23 Aug. 1483 The Council voted to recognise the word Methadon as the generic designation for 6-dimethylamino-4,4-diphenyl-3-heptanone. 1948Ann. N.Y. Acad. Sci. LI. 17 It is not certain whether the Germans succeeded in the complete resolution of dl-methadone. 1952W. T. Salter Textbk. Pharmacol. vi. 81/1 The danger of addiction of racemic methadon and levo-methadon is about equal to that of morphine. 1962K. Orvis Damned & Destroyed xxiii. 174 A new drug, methadon, is being used successfully as a reduction treatment... The patient starts regaining strength—moral and physical strength—almost at once. 1967Martindale's Extra Pharmacopoeia (ed. 25) 783/1 Symptoms of morphine withdrawal in addicts may also be mitigated by methadone substitution; addiction to methadone is easier to treat than addiction to morphine. Ibid. 800/2 Methadone hydrochloride may be used for the relief of severe pain of all types. 1970Sunday Times 8 Mar. 1/2 She was taking big doses of heroin three times a day, together with the morphine-antagonist, methadone,..every four hours. 1971Guardian 4 June 3/3 The aim of the methadone programme is to switch the mainliner's addiction from heroin to methadone, an addictive drug..which allows its addicts to lead a normal life... The methadone programme was begun in New York in 1965 by the Beth Israel Medical Centre. 1972Science 26 May 882/2 Methadone not only reduces the hunger for heroin, it affects respiration, digestion, and sexual behavior; it also, as does any opiate, affects social and psychological behavior. |