| 释义 |
metalation Chem.|mɛtəˈleɪʃən|
[f. metal n. + -ation.]
The introduction into an organic compound of an atom of a metal in place of one of hydrogen (usu. one attached to an aromatic ring).
1934Gilman & Young in Jrnl. Amer. Chem. Soc. LVI. 1415/1 The term metalation is proposed for reactions involving replacement of hydrogen by a metal to give a true organometallic compound. Ibid., Metalations were effected by metals, organometallic compounds and salts. 1937F. C Whitmore Org. Chem. 724 The aniline sulfate solution contains the strongly positive group {b1}NH3 and consequently gives m-substitution. The ‘metalation’ of benzine apparently offers an exception to this generalization. 1957E. G. Rochow et al. Chem. Organometallic Compounds iii. 54 Metalation reactions occur only with the derivatives of the strongly electropositive alkali and alkaline earth metals and, rarely, magnesium. 1968R. O. C. Norman Princ. Org. Synthesis xi. 392 Electrophilic metalations by metal salts should not be confused with the metalation of aromatic compounds with metal.
Hence (as a back-formation) ˈmetalate v. trans., to bring about metalation in; ˈmetalated, ˈmetalating ppl. adjs.
1939Jrn. Amer. Chem. Soc. LXI. 109/2 Phenyl ether was not metalated by triphenylmethylsodium. 1954Organic Reactions VIII. vi. 260, n-Butyllithium metalates thiophene in the 2 position. Ibid. 261 The usual metalating agents..yield volatile acids which are easily separated from the acids of higher molecular weight obtained from the metalated products themselves. 1966McGraw-Hill Encycl. Sci. & Technol. IX. 402/2 The most commonly used ‘metalating agent’..is n-butyllithium in ether solution. |