| 释义 |
Promin Pharm.|ˈprəʊmɪn|
Also promin.
A proprietary name in the U.S. for a glucoside derivative of 4,4′-diaminodiphenyl sulphone, C12H12N2O2S, which has a bacteriostatic action and has been used esp. to treat leprosy.
1937Official Gaz. (U.S. Patent Office) 29 June 1008/2 Parke, Davis & Company, Detroit... Promin. For p-amino-benzene-sulfonamide used in treatment of streptococcic infections. Claims use since April 16, 1937. 1939Canad. Med. Assoc. Jrnl. XL. 319/1 The following compounds have been investigated: p-aminobenzene sulphonamide (sulphanilamide),..a glucoside derivative of 4:4′ diamino diphenyl sulphone (promin). 1948Call-Bulletin (San Francisco) 12 Apr. 3/6 Diasone and two companion drugs, promin and promizole, have shown promise against both tuberculosis and leprosy but they have some disadvantages. 1958New Scientist 11 Sept. 798/2 Eventually it was found by Dr. John Lowe in 1948 that the simpler parent compound—diamino diphenyl sulphone..(now called dapsone) was more active than promin. 1971W. H. Jopling Handbk. Leprosy vi. 52 Dapsone..had the advantage over Promin of being much cheaper and of being suitable for oral administration (Promin has to be given intravenously). |