| 释义 |
kynurenine Biochem.|kɪ-, kaɪnjʊˈrɛniːn|
[ad. G. kynurenin (Kotake & Iwao 1931, in Zeitschr. f. physiol. Chem. CXCV. 140), f. kynuren-säure, *kynurenic acid: see -ine5.]
A crystalline amino-acid, H2N·C6H4·COCH2CH(NH2)COOH, that results from the metabolism of tryptophan and is a precursor of kynurenic acid in man and various animals; β-ο-aminobenzoylalanine.
1931Chem. Abstr. XXV. 2444 When tryptophan is injected subcutaneously into rabbits whose metabolism has been lowered by a regime of polished rice, a product intermediate between tryptophan and kynurenic acid is excreted in the urine. The name kynurenine is proposed for this substance. 1938H. Gilman Orig. Chem. II. 943 An amino acid, kynurenine, in which the pyrrole ring of tryptophan has ruptured. 1946,1971[see kynurenic a.]. 1972Chem. Abstr. LXXVII. 16364 l-Kynurenine, colorless needles from EtOH, m. 194°, was obtained in a yield of 120 mg from 30 g of rat hair by extn. with hot water and sepn. on a Sephadex column. |