| 释义 |
kallikrein Biochem.|ˈkælɪkriːɪn, -kriːn|
Also † callicrein.
[a. G. kallikrein (H. Kraut et al. 1930, in Zeitschr. f. physiol. Chem. CLXXXIX. 99), f. Gr. καλλίκρε-ας sweetbread (f. καλλι-, comb. form of κάλλος beauty + κρέας flesh): see -in1.]
a. An enzyme found in the human pancreas and elsewhere in the body, which releases kallidin from a plasma precursor and has been used therapeutically as a vasodilator and hypotensive agent.
1930Chem. Abstr. XXIV. 4541 The name callicrein, taken from a Greek synonym for pancreas, is proposed for this circulatory hormone. 1956Robson & Keele Recent Adv. Pharmacol. (ed. 2) xiv. 480 Kallidin is formed by the proteolytic action of a widely distributed (in saliva, serum, urine, pancreas, etc.) enzyme called Kallikrein, which under the name Padutin has been used therapeutically. 1967Martindale's Extra Pharmacopoeia (ed. 25) 1440 Kallikrein is a dilator of the peripheral blood-vessels... It has been used in the treatment of vasospastic circulatory disorders, including..chilblains.
b. Any enzyme which liberates a kinin from a protein.
1966M. E. Webster in E. G. Erdös Hypotensive Peptides 650 A kallikrein is defined as an endogenous enzyme which rapidly and specifically liberates a kinin from kininogen... In view of the many known chemical and physical differences between the kallikreins, each kallikrein should be identified by species and source, e.g. hog pancreatic kallikrein. 1969Physiol. Rev. XLIX. 510 The kallikreins (kininogenases) are a group of enzymes... They have marked actions on blood vessels and smooth muscles in vivo that..are due to the rapid enzymatic cleavage of a specific substrate, an α2 globulin present in plasma and lymph. |