| 释义 |
isocarboxazid Pharm.|ˌaɪsəʊkɑːˈbɒksəzɪd|
[f. isocarbox- (by rearrangement of part of the chemical name: see quot. 1959) + hydrazide.]
A whitish powder that is a hydrazine derivative, C6H5CH2NH·NHCO·C3HNO·CH3, and is used as an antidepressant.
1959Diseases Nervous Syst. XX. 269/1 An analog of iproniazid, isocarboxazid.., has been used in pharmacological studies which show it to be a more potent amine oxidase inhibitor than its progenitor. Its chemical formula is 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)-hydrazine. 1963Jrnl. Amer. Med. Assoc. 16 Mar. 952/1 It is the opinion of the Council that isocarboxazid seems to be effective in the depressed phases of anxiety and manic-depressive states as well as in certain involutional, obsessive, and disassociative reactions. 1965J. Pollitt Depression & its Treatment iv. 56 The monoamine oxidase inhibitors include several members, among them phenelzine (Nardil), iproniazid (Marsilid), isocarboxazid (Marplan). |