| 释义 |
▪ I. villin
obs. f. villain n.
▪ II. villin, n. Biochem.|ˈvɪlɪn|
[f. villus n. + -in1.]
A protein found in the microvilli of the small intestine and involved in the calcium-dependent cleaving of actin microfilaments, and hence in the regulation of cell motility.
1979Bretscher & Weber in Proc. Nat. Acad. Sci. LXXVI. 2321/2 Here we describe the isolation of the 95,000 molecular weight protein, which we call villin, and show that it is immunologically and functionally distinct from α-actinin. 1987Nature 16 Apr. 646/2 Small regions of the synapsin sequence are 40–50 per cent identical to villin, a calcium-dependent actin severing and bundling protein, and profilin, a protein that sequesters actin monomers. 1988P. W. Kuchel et al. Schaum's Outl. Theory & Probl. Biochem. v. 125 Villin, a major protein of the microvilli of the intestinal brush border..will also fragment (sever) the filament. |