| 释义 |
valproic, a. Pharm.|vælˈprəʊɪk|
[f. valeric a. + propyl + -ic.]
2-Propylpentanoic acid, C8H15OOH, a branched-chain fatty acid; also, a salt of this. Hence valˈproate, a salt of this acid, esp. the sodium salt, an anticonvulsant drug given orally in cases of epilepsy.
1972Approved Names (Brit. Pharmacopœia Commission) Suppl. iv. 6 Valproic acid. 1974Brit. Med. Jrnl. 15 June 584/1 The anticonvulsant effects of sodium dipropylacetate (sodium valproate) were first reported in France. 1977Lancet 22 Oct. 860/1 The antiepileptic activity of valproic acid (dipropylacetic acid) was recognized serendipitously when the agent was administered to animals as a vehicle for a series of test compounds. 1983F. E. Dreifuss in Pedley & Meldrum Rec. Adv. in Epilepsy I. iii. 35 Clinical experience with Valproate extends over nearly 20 years. Ibid., The term Valproate is used here to refer both to valproic acid and its salts (sodium or magnesium). |