| 释义 |
ibotenic, a. Biochem.|iːbəʊˈtɛnɪk|
[f. Jap. iboten(gutake, the name of the mushroom (Amanita strobiliformis) from which the acid was first isolated + -ic.]
ibotenic acid, an isoxazole, C5H6N2O4H2O , found in certain mushrooms of the genus Amanita, and used as an insecticide and experimentally as a highly selective neurotoxin.
1962New Scientist 28 June 709/3 He [sc. Prof. Tsunematsu Takemoto] extracted ibotenic acid from Amanita strobiliformis, a mushroom known as ‘ibo tengu dake’ in Japanese. 1964T. Takemoto et al. in Yakugaku Zasshi LXXXIV. 1186 The compound is considered to be an unknown acidic amino acid and is called ibotenic acid, naming [sic] after the ibotengutake. 1970Brain Res. XXIV. 368 Most neurones that responded to l-glutamic acid were also excited by the electrophoretic administration of l-α-allo-kainic acid, l-α-kainic acid, tricholomic acid, and ibotenic acid. 1981Verbatim Autumn 2/2 A fly may be stupefied by the ibotenic acid contained in A[manita] muscaria and then may die by ‘misadventure’. 1987J. N. P. Rawlins in S. M. Stahl et al. Cognitive Neurochem. vi. 78 An alternative excitatory neurotoxin, ibotenic acid, seems to be preferable if really selective lesions are to be made. 1988Brit. Med. Jrnl. 21 May 1469/1 The recipient of the tissue from the 80 day fetus had previously had a unilateral ablation of the cholinergic input to the hippocampus using ibotenic acid.
Hence iˈbotenate n., a salt of ibotenic acid.
1976Jrnl. Physiol. CCLV. 453 Hyperpolarization of the membrane by current injection abolished the hyperpolarizing response to glutamate and ibotenate at the same membrane potential level. 1983Neuroscience VIII. 819 Some cell groups, such as those in the medial septum and the locus coeruleus, proved highly resistant to kainate but could be selectively ablated by ibotenate. |