| 释义 |
hypermutation, n. Genetics.
Brit. |ˌhʌɪpəmjuːˈteɪʃn|, U.S. |ˈˌhaɪpərˌmjuˈteɪʃ(ə)n|
[‹ hyper- prefix + mutation n. With sense 2 compare slightly earlier hypermutability n.]
1. A mutation resulting in a major phenotypic change. rare. disused.
1934W. H. Manwaring in Science 25 May 468/2 Similar hyper-mutations are known to occur during the course of natural clinical infections.
2. Mutation occurring at a high rate; frequent mutation; a form resulting from such mutation.
1966Proc. Royal Soc. (B.) 166133 Multiple structural differences could arise from a variety of mechanisms, for example, an accumulation of point mutations, hypermutation, somatic chromosomal rearrangements, [etc.]. 1977Science 29 July 450/2 [This] would in turn lead to a hypermutation-induced expansion of the antibody repertoire. 1996Economist 16 Nov. 140/2 Work on captive laboratory bacteria has generally found that hypermutation is rare, as the conventional wisdom would suggest. 2003Blood 1014047 The base pair substitutions within the rearranged V(H) genes represent hypermutations. |