| 释义 |
hypermutable, a. Genetics.
Brit. |ˌhʌɪpəˈmjuːtəbl|, U.S. |ˌhaɪpərˈmjudəb(ə)l|
[‹ hyper- prefix + mutable adj. Compare slightly earlier hypermutability n.]
Undergoing or characterized by frequent mutation; highly prone to mutation; highly susceptible to mutagenesis.
1960New Biol. 31 105 Its main assumptions, however—e.g. that individual mesenchymal cells are..hypermutable, and that they are stimulated to proliferate and produce antibody by contact with antigen—are far from proved. 1978Molecular & Gen. Genetics 163307 [These] mutants however were not found to be hypermutable by UV light. 1989A. J. Jefferys in J. R. Durant Human Origins iii. 43 These convergences may be due to specific nucleotide sites which are hypermutable for some biochemical reason. 2001Cytogenetics & Cell Genetics 92 177 A second pathway toward malignancy has emerged..characterized..by inactivation of the DNA mismatch repair system, leading to a hypermutable state in which simple repetitive DNA sequences are unstable during DNA replication. |