| 释义 |
histone Biochem.|ˈhɪstəʊn|
Formerly also -on.
[ad. G. histon (A. Kossel 1884, in Zeitschr. f. physiol. Chem. VIII. 512), perh. f. Gr. ἱστ-άναι to arrest or ἱστ-ός histo-: see -one.]
Any of a small class of simple, basic proteins which are soluble in water and dilute acids but insoluble in dilute ammonia and which are most commonly found in association with nucleic acids.
1885Jrnl. Chem. Soc. XLVIII. i. 572 Extraction with dilute acid isolates a substance which belongs to the class of bodies called A-peptones by Meissner... The author names this substance histon. 1905C. E. Simon Physiol. Chem. (ed. 2) 194 The protamins are decomposed entirely like the albumoses and peptones, while the histons are only affected in part, which coincides with the position which the histons occupy midway between the protamins and the true albumins. 1952Sci. News XXIV. 37 Histones..are present in appreciable amounts in the nuclei of the tissue cells of all animal species examined. 1968New Scientist 7 Nov. 319/3 What now seems much more possible is that the histones are simply the tool needed to shut down genes, and that they are instructed which particular gene..to shut down by another, specific, molecule. |