| 释义 |
heparin Biochem.|ˈhɛpərɪn|
[f. hepar + -in1.]
A sulphated polysaccharide present in various body tissues and organs, esp. the liver, lungs, and muscles, and used therapeutically as an anti-coagulant.
1918Howell & Holt in Amer. Jrnl. Physiol. XLVII. 328 A phosphatid, not previously described, which exists in various tissues but is found in greatest abundance in the liver. This phosphatid is designated as heparin to indicate its origin from liver... This substance was [previously] described under the name of antiprothrombin. 1933Jrnl. Biol. Chem. CII. 435 Dog liver contains approximately twice as much heparin as does beef liver. 1946Nature 24 Aug. 270/1 Even drastic blood changes brought about by the injection of dicoumarol or heparin had only a slight effect on the rate of growth of the bugs. 1968A. White et al. Princ. Biochem. (ed. 4) xxxi. 732 Many tissues of the body contain heparin since it specifically originates in the metachromatic granules of mast cells.
Hence ˌhepariniˈzation, the process of heparinizing; ˈheparinize v. trans., to treat with heparin and thus reduce the clotting power of the blood; ˈheparinized ppl. a.
1940J. E. R. McDonagh Universe through Med. 24 Snake venom has the same action in this condition as has calcium in making heparinised blood coagulate. 1943Science 2 July 20/1 In all experiments in which heparinized whole blood or plasma was administered the lipemia was abolished. 1956New Eng. Jrnl. Med. 29 Nov. 1027/2 General heparinization carries with it the risk of serious hemorrhage from bleeding lesions elsewhere in the body as well as at the operative site. 1959Lancet 11 July 25/1 The risk of heparinising a patient who is receiving a coumarin drug. 1961Ibid. 14 Oct. 858/1 The principle of regional heparinisation is to supply anticoagulated blood to the artificial kidney, whilst not interfering with the normal coagulation of blood in the patient. |