| 释义 |
haptophore, a. (and n.) Immunol.|ˈhæptəʊfɔə(r)|
Also -phor.
[a. G. haptophor (P. Ehrlich 1898, in Deutsch. med. Wochenschr. 22 Sept. 599/2), f. Gr. ἅπτειν to fasten + -o + -phore.]
Applied, in Ehrlich's theory of immunization, to that group of atoms in the molecule of a toxin or other substance which enables it to combine with the corresponding receptors of a cell. Also absol. So haptoˈphoric, hapˈtophorous adjs.
1899tr. P. Ehrlich in Trans. Jenner Inst. Prevent. Med. (2nd Ser.) 11, I have already..touched upon the question whether..the toxin molecule contains two independent groups, of which the one (the toxophore) conditions the toxicity, and the other (the haptophore) the combining property. Ibid. 12 With the help of the haptophore groups, the toxin molecule becomes ‘anchored’ to the cell. 1902Vaughan & Novy Cellular Toxins (ed. 4) 182 Both the toxophil groups of the cell, and the cytophil groups of the toxin may be designated as haptophorous bodies. 1902Brit. Med. Jrnl. 29 Mar. 785 The atom arrangement, or group in the toxin, which corresponds to the receptor, he [sc. Ehrlich] calls the ‘haptophoric group’. 1904Ibid. 10 Sept. 574 Although the toxophoric group may be similar, the haptophor is dissimilar. 1938W. Bulloch Hist. Bacteriol. xi. 275 Of the two, the haptophore is the more stable. Ehrlich considered that the toxophoric atom group can deteriorate to a non-toxic state although the haptophoric group may at the same time remain unchanged. 1960New Biol. XXXI. 104 It was very hard to conceive that ‘haptophores’ could pre-exist. |