| 释义 |
Albright, n. Path.|ˈɔːlbraɪt|
[The name of Fuller Albright (1900–69), U.S. endocrinologist.]
a. Albright('s) syndrome, Albright's fibrous dysplasia [described by Albright et al. in New England Jrnl. Med. (1937) 29 Apr. 727], a rare disease characterized by fibrous dysplasia of bone tissue, brownish patchy pigmentation of the skin, and endocrine disturbances, including precocious puberty in females.
1940Q. Cumulative Index Medicus XXVI. 974/2 Osteitis..fibrosa, case with precocious puberty and cutaneous pigmentation (Albright syndrome). 1965R. H. Durham Encycl. Med. Syndromes 19 Differential diagnosis should exclude hyperparathyroidism.., for in Albright's syndrome considerable portions of the skeleton are unaffected. 1987R. Wynne-Davies in S. P. F. Hughes et al. Orthopaedics xix. 420/1 Polyostotic fibrous dysplasia..is characterized by the development of fibrous tissue within bone at multiple sites. In Albright's fibrous dysplasia this feature is associated also with patches of brown skin pigmentation and, in girls, with gonadal dysfunction and precocious puberty.
b. Albright('s) (hereditary) dystrophy [tr. F. dystrophie d'Albright (coined by P. Seringe & S. Tomkiewicz 1957, in Ann. de Pédiatrie XXXIII. 1099/1); described by Albright et al. in Endocrinology (1942) XXX. 922 and Trans. Assoc. Amer. Physicians (1952) LXV. 337], Albright('s) (hereditary) osteodystrophy, the conditions pseudohypoparathyroidism and pseudopseudohypoparathyroidism.
1957Current List Med. Lit. XXXII. 313/2 Albright's dystrophy: pseudo-pseudo-hypoparathyroidism of other authors. 1962Ann. Internal Med. LVI. 335/1 The ossification or calcification of Albright's hereditary osteodystrophy is subcutaneous. 1993Jrnl. Clin. Endocrinol. & Metabolism LXXVI. 1560/2 Activity of G5α protein is reduced in most subjects with Albright hereditary osteodystrophy (AHO), an inherited disorder characterized by a constellation of somatic and developmental defects. |