| 释义 |
tyrosinosis Med.|taɪrəsɪˈnəʊsɪs|
[f. tyrosine + -osis.]
A rare condition of unknown ætiology in which there is increased excretion of the early metabolites of tyrosine but no liver or kidney damage; also (now rare) = tyrosinæmia.
1932G. Medes in Biochem. Jrnl. XXVI. 938 The essential feature in our patient..consists in a complete stoppage of the oxidation of tyrosine at the stage of p-hydroxyphenylpyruvic acid... Thus results an excretion not only of p-hydroxyphenylpyruvic acid and..l-p-hydroxyphenyllactic acid, but also of tyrosine and..l-3:4-dihydroxyphenylalanine. For this condition, the name tyrosinosis is proposed. 1942[see l-dopa]. 1969[see homocystinuria s.v. homocystine]. 1974Passmore & Robson Compan. Med. Stud. III. xlvii. 8/1 Formerly hypertyrosinaemia or tyrosinosis was considered to be a single, exceedingly rare abnormality. 1982T. I. Diamondstone in T. M. Devlin Textbk. Biochem. xii. 589/1 Tyrosinosis and the tyrosinemias have certain biochemical features in common. |