| 释义 |
transgenic, a. and n. Biol.|trɑːnsˈdʒɛnɪk, træns-, -nz-|
[f. trans- 10 + -genic a.]
A. adj. Of an organism: containing genetic material into which DNA has been artificially introduced into the germ line. Also applied to the cells of a transgenic organism.
1981Gordon & Ruddle in Science 11 Dec. 1244/3 The feasibility of producing such genetically transformed mice, which we call ‘transgenic’ mice, depends upon several factors. 1985Cell XLII. 124/2 In other transgenic pre-B cells, sufficient µ synthesis precedes DNA rearrangement and inhibits it. 1989E. Lawrence Guide Mod. Biol. iv. 101 Transgenic organisms can be raised that carry potentially useful genes from a wide variety of species. 1990Independent 24 Apr. 21/2 Patenting comes next for these transgenic animals.
B. n.
1. pl. (usu. const. as sing.). The branch of biology concerned with the creation and investigation of transgenic organisms. Cf. transgenosis n.
1986Trends in Biotech. IV. 32/1 (heading) Intransigence in ‘genetic engineering’: transgenics or generics. 1988Sunday Times 22 May d18/6 The other half [of the new money] will be devoted to development of transgenics, the adding of foreign genes to animals to enhance their properties. 1989New Scientist 21 Jan. 25/1 The HSE wants all work on transgenics, which falls within the definition of genetic manipulation, to be notified to a local Genetic Manipulation Safety Committee.
2. A transgenic organism. Usu. in pl.
1989Nature 26 Jan. 300/2 It is important that those involved in the production of transgenics should be seen to be taking particular care over this aspect of their work, for example by including it on the agenda of international meetings. 1991Weekend Australian (Brisbane) 29–30 June 7/5 Any escape of transgenics was highly unlikely.
Hence (as a back-formation) ˈtransgene n., a gene which is introduced into the genome of another organism.
1985Cell XLII. 124/2 The most probable explanation for these results is that transcription of the µ transgene is initially too low early in B cell differentiation to block heavy chain rearrangement totally. 1988Nature 1 Dec. 446/1 The pathway of B-cell development was perturbed in the tester strain by introducing a transgene encoding the membrane-bound form of the immunoglobulin heavy chain. |