| 释义 |
procarbazine Pharm.|prəʊˈkɑːbəziːn|
[f. propyl + carbamic a. + hydrazine, formative elements of the systematic name.]
A hydrazine derivative whose hydrochloride is used in the treatment of some neoplastic diseases, esp. Hodgkin's disease; N-p-isopropylcarbamoylbenzyl-N'-methylhydrazine, C12H19N30.
1965Brit. Med. Jrnl. 18 Dec. 1473/1 (heading) Natulan (procarbazine) combined with radiotherapy in management of inoperable malignant melanoma. 1974R. M. Kirk et al. Surgery iv. 58 Hodgkin's disease (Lymphadenoma)... Generalized disease responds to chemotherapy, usually with a combination of vincristine, mustine, procarbazine and prednisone in pulsed doses. 1977Lancet 14 May 1041/2 Of all cytotoxic drugs the teratogenicity of the alkylating agents is particularly well-documented; these, and procarbazine too, are best avoided at all stages of pregnancy if possible. |