| 释义 |
tosyl Chem.|ˈtɒsɪl|
[a. G. tosyl (Hess & Pfleger 1933, in Ann. d. Chemie DVII. 48), f. toluolsulfonyl: see toluol (s.v. tolu-), sulphonyl.]
The para isomer of the univalent radical toluenesulphonyl, H3C·C6H4·SO2—.
1938Jrnl. Amer. Chem. Soc. LX. 398/1 The unimolar tosylation of α- and β-methyl-d-glucosides in pyridine solution with tosyl chloride, followed by acetylation results in the formation of 6-tosyl-triacetyl-α-methyl-d-glucoside. 1975Nature 30 Oct. 763/1 There is no evidence for a hydrophobic binding pocket or tosyl hole as seen in the α-chymotrypsin structure.
Hence ˈtosylate n., an ester of the tosyl group; v. trans., to introduce a tosyl group into (a compound) or add one to (an atom); ˈtosylated, ˈtosylating ppl. adjs.; tosyˈlation, the process of tosylating.
1938Jrnl. Amer. Chem. Soc. LX. 1203/2 The structure of this compound may be considered proved since it is identical with that obtained..upon tosylating 2,3,4,2′,3′–pentaacetyl-β-methylcellobioside. 1938[see tosyl above]. 1963I. L. Finar Org. Chem. (ed. 4) I. xxv. 612 Tosylates are useful for preparing, e.g., ethers. 1972Jrnl. Chem. Soc.: Chem. Communications 1148/1 We have found that N-methyl-N-tosylpyrrolidinium perchlorate..can be used as a selective tosylating reagent. Ibid. 1149/1 We assumed that only nitrogen would be tosylated if both amino- and hydroxy-groups were present in the substrate. 1974Jrnl. Org. Chem. XXXIX. 635/2 A greater chemical shift difference was observed for the C-2 ring protons adjacent to the tosylated nitrogen. Ibid., Tosylation was carried out with tosyl chloride in the usual basic media of pyridine or aqueous sodium bicarbonate. 1978J. M. & D. J. Cram Essence Org. Chem. vi. 150 The name p-toluenesulfonyl group (Ar—SO2—) is shortened to the ‘tosyl’ group, and the ester is ethyl tosylate. |