释义 |
thioctic, a. Chem.|θaɪˈɒktɪk| [f. thio- + octa- + -ic.] thioctic acid: any of the sulphur-containing acids with the formula S{b1}S{b1}CH2(CH2)xCH(CH2)5-xCOOH, where x = 1, 2, 3, 4, or 5; spec. 6,8-dithio-n-octanoic acid (x = 1), = α-lipoic acid s.v. lipo-.
1952J. A. Brockman et al. in Jrnl. Amer. Chem. Soc. LXXIV. 1868/2 The name ‘thioctic acid’ is proposed for this structure (x = 2), a sulfur-containing organic acid with 8 carbon atoms. 1953Fruton & Simmonds Gen. Biochem. xxxviii. 900 Recent work has assigned to α-lipoic acid..the structure of 6,8-dithio-n-octanoic acid (‘6-thioctic acid’). Isomers of this compound such as the 4,8-dithio acid (‘4-thioctic acid’) or the 5,8-dithio acid (‘5-thioctic acid’) have less POF [sc. pyruvate oxidation factor] activity. 1975Sci. Amer. Mar. 98/2 In the 1950's thioctic acid had been proposed as a remedy for liver damage caused by heavy-metal poisoning. |