| 释义 |
thalassæmia Path.|θæləˈsiːmɪə|
Also (chiefly U.S.) -emia.
[f. thalasso- + Gr. αἷµα blood + -ia1.]
A hereditary hæmolytic anæmia common in malarious (or formerly malarious) areas and caused by the faulty synthesis of part of the hæmoglobin molecule, with symptoms that depend on the part of the molecule affected and on whether the individual is homozygous or heterozygous for the gene concerned; so thalassæmia major, thalassæmia intermedia, thalassæmia minor.
1932Whipple & Bradford in Amer. Jrnl. Dis. Children XLIV. 364 We do not like the term ‘erythroblastic anemia’... The disease is limited almost wholly to Italians, Greeks and Syrians, i.e., to the people originating about the Mediterranean Sea. For this reason the term ‘thalassemia’..may have an appeal. 1936, etc. [see Mediterranean n. 1 b]. 1944Valentine & Neel in Arch. Internal Med. LXXIV. 196/2 It is suggested, on the basis of the pathologic and genetic evidence, that the full-blown disease be designated ‘thalassemia major’ and the milder carrier state ‘thalassemia minor’. 1954K. Singer et al. in Blood IX. 1039 We have found the following simple classification very useful; it is based on the alterations of the red cell and hemoglobin levels: 1. Thalassemia major (Cooley's anemia): very severe microcytic hemolytic anemia. 2. Thalassemia intermedia, characterized by a less severe, but still marked anemia. 3. Thalassemia minor: mild anemia. 1962[see haemoglobinopathy]. 1972D. E. Comings in W. J. Williams et al. Hematology xxxi. 332/2 Although the total number of individuals with thalassemia intermedia is relatively small.., it constitutes a clinically important group, since its relatively benign course (compared to thalassemia major) allows affected individuals to live to adulthood. 1973B. J. Williams Evolution & Human Origins iv. 61/2 Osteoporosis occcurs even with thalassemia minor. 1978Jrnl. R. Soc. Med. LXXI. 465/1 The hepatic cirrhosis of thalassaemia major. 1979Brit. Med. Jrnl. 17 Nov. 1298/2 The 26-year-old Chinese with beta-thalassaemia who had been transfused with 404 units of blood in his lifetime. His total body iron was so high that it triggered the alarm at an airport security checkpoint. 1982New Scientist 21 Jan. 164/1 Red blood cells in people with thalassæmia cannot carry oxygen well enough, and patients survive only with regular blood transfusions.
Hence thalaˈssæmic, a person with thalassæmia.
1974Nature 8 Feb. 380/1 The δβ-thalassaemics were Sicilian and have been previously reported. 1979Ibid. 15 Nov. 317/2 In one study, the incidence of HbF Sardinia in β-thalassaemics in Italy was 90%, compared with only 40% in normal Italians. |