| 释义 |
ethionamide Pharm.|ɛθɪˈɒnəmaɪd|
[Blend of ethyl and thion- + amide.]
An antibiotic, C8H10N2S, which is active against mycobacteria and has been used to treat tuberculosis.
1960Tubercle XLI. 367 Ethionamide..is given orally in small bulk, is highly effective and is of low toxicity. 1974[see pyrazinamide]. 1983Oxf. Textbk. Med. I. v. 254/1 The use of ethionamide and prothionamide..is limited by their adverse effects, notably gastrointestinal irritation. 1984Brit. Med. Jrnl. 25 Aug. 496/1 It is difficult to establish whether liver damage has been due to rifampicin or one of its companion drugs (such as isoniazid and ethionamide), which may form potentially hepatotoxic combinations with rifampicin. |